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Must exosomes observed by electron microscopy have a membrane structure? Are spherical structures without a membrane correct?
In EM images, the morphology of exosomes should show a distinct cup-shaped or saucer-like structure. Generally, there is a slightly brighter rim at the edge of the exosome. If structures without a membrane are seen in EM results, they might not be exosomes; they could be lipoprotein particles or proteins.
Can NTA be used for exosome quantification?
NTA can be used for particle counting. However, quantifying exosomes based on particle number typically leads to overestimation because exosome samples may contain lipoproteins, protein aggregates, and other impurities that are also counted.